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Experimental studies suggest that Mn excess promotes hepatic steatosis through oxidative stress and insulin resistance, while Mn deficiency impairs mitochondrial antioxidant defense and lipid metabolism (Hu et al., 2025

95% CI 4.83 to 207.35) but acknowledged that this appears different from the sometime premalignant endometrial hyperplasia associated with unopposed estrogen treatment

The shot delivers a high dose of therapeutic B12, usually in the form of cyanocobalamin or hydroxocobalamin

For these agents, specific reversal strategies include idarucizumab (for dabigatran) or andexanet alfa (for factor Xa inhibitors) where available